I find the great thing in this world is not so much where we stand, as in what direction we are moving: To reach the port of heaven, we must sail sometimes with the wind and sometimes against it, — but we must sail, and not drift, nor lie at anchor.

Oliver Wendell Holmes, Sr. (1809-1894) American poet, essayist, scholar

Article (1858-02), “The Autocrat of the Breakfast-Table,” Atlantic Monthly
    (Source)

Collected in The Autocrat of the Breakfast Table, ch. 4 (1858).