It is of the first importance not to allow your judgment to be biased by personal qualities. A client is to me a mere unit, a factor in a problem. The emotional qualities are antagonistic to clear reasoning. I assure you that the most winning woman I ever knew was hanged for poisoning three little children for their insurance-money, and the most repellent man of my acquaintance is a philanthropist who has spent nearly a quarter of a million upon the London poor.

Arthur Conan Doyle (1859-1930) British writer and physician

Story (1890-02), “The Sign of the Four,” ch. 2 [Holmes], Lippincott’s Monthly Magazine, Vol. 45 (US) / 1 (UK)
    (Source)

The original publication, and Doyle's manuscript (along with many other iterations across media) use "The Sign of the Four" as the title, while others (including the first book publications) use "The Sign of Four." The five-word form is used most commonly in the story, but the four-word form does show up. (More info.)

Published in novel form as The Sign of Four (1890-10).