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Nothing has more retarded the advancement of learning than the disposition of vulgar minds to ridicule and vilify what they cannot comprehend.

Samuel Johnson (1709-1784) English writer, lexicographer, critic
The Rambler, #117 (30 Apr 1751)
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Presented as a letter from "Hypertatus"
 
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… [P]riests of the different religious sects, who dread the advance of science as witches do the approach of day-light; and scowl on the fatal harbinger announcing the subversion of the duperies on which they live.

Thomas Jefferson (1743-1826) American political philosopher, polymath, statesman, US President (1801-09)
Letter to José Corrêa da Serra (11 Apr 1820)
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On resistance, particularly from Presbyterians, to the founding of the University of Virginia.
 
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Books must follow sciences, and not sciences books.

Francis Bacon (1561-1626) English philosopher, scientist, author, statesman
Resuscitatio, “Proposition Touching Amendment of Laws” (1657)
 
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What separates me from most atheists is a feeling of utter humility toward the unattainable secrets of the harmony of the cosmos. The fanatical atheists are like the slaves who are still feeling the weight of their chains which they have thrown off after hard struggle. They are creatures who — in their grudge against traditional religion as the “opium of the masses” — cannot hear the music of the spheres. I prefer the attitude of humility corresponding to the weakness of our intellectual understanding of nature and our own being. Science without religion is lame, religion without science is blind.

Albert Einstein (1879-1955) German-American physicist
(Spurious / Synthetic)

This quotation is actually a synthesis of several Einstein quotes. It is sometimes attributed as a whole to "Science, Philosophy and Religion, A Symposium" (1941), but only a part is found there. Nor is it found at all  in the also sometimes cited "Religion and Science," New York Times Magazine (9 Nov 1930)

The "utter humility" portion is attributed as a letter from Einstein to Joseph Lewis (18 Apr 1953).  It was quoted in Walter Isaacson, Einstein (2007). The “fanatical” through “spheres” portion is in a letter (7 Aug 1941) discussing responses to his essay “Science and Religion” (1941) per Max Jammer, Einstein and Religion: Physics and Theology (1999)

The “weakness of our intellectual understanding” phrase is attributed to a letter to Guy H. Raner Jr. (28 Sep 1949), quoted in the Isaacson work as well as by Michael R. Gilmore in Skeptic, Vol. 5, No. 2.

The lame/blind phrase is attributed to a letter to Eric Gutkind (3 Jan 1954). It was earlier used by Einstein (1941) at the Symposium cited above.

This synthetic quotation is a good example of the difficulties in quoting Einstein, who is used as a polemical bludgeon by a variety of groups, and is often poorly or incorrectly cited online, compounded by his re-use the same turns of phrase multiple times in his correspondence and papers.
 
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How can cosmic religious feeling be communicated from one person to another, if it can give rise to no definite notion of a God and no theology? In my view, it is the most important function of art and science to awaken this feeling and keep it alive in those who are receptive to it.

Albert Einstein (1879-1955) German-American physicist
“Religion and Science,” New York Times Magazine (9 Nov 1930)
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There are two classes [of scientists], those who want to know and do not care whether others think they know or not, and those who do not much care about knowing but care very greatly about being reputed as knowing.

Samuel Butler (1835-1902) English novelist, satirist, scholar
The Note-Books of Samuel Butler, “Scientists” (1912)

Full text.

 
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Science is a way of trying not to fool yourself. The first principle is that you must not fool yourself, and you are the easiest person to fool.

Richard Feynman (1918-1988) American physicist
“What Is and What Should Be the Role of Scientific Culture in Modern Society,” lecture at the Galileo Symposium, Italy (1964)
 
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No government has the right to decide on the truth of scientific principles, nor to prescribe in any way the character of the questions investigated. Neither may a government determine the aesthetic value of artistic creations, nor limit the forms of literacy or artistic expression. Nor should it pronounce on the validity of economic, historic, religious, or philosophical doctrines. Instead it has a duty to its citizens to maintain the freedom, to let those citizens contribute to the further adventure and the development of the human race.

Richard Feynman (1918-1988) American physicist
The Meaning of It All, “The Uncertainty of Values” (1999)
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The Religion that is afraid of science dishonours God and commits suicide.

Ralph Waldo Emerson
Ralph Waldo Emerson (1803-1882) American essayist, lecturer, poet
Journal (1831-03-04)
 
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Reason, Observation and Experience — the Holy Trinity of Science — have taught us that happiness is the only good; that the time to be happy is now, and the way to be happy is to make others so. This is enough for us. In this belief we are content to live and die. If by any possibility the existence of a power superior to, and independent of, nature shall be demonstrated, there will then be time enough to kneel. Until then, let us stand erect.

Robert Green Ingersoll (1833-1899) American lawyer, agnostic, orator
“The Gods” (1876)
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We cannot define anything precisely! If we attempt to, we get into that paralysis of thought that comes to philosophers who sit opposite each other, one saying to the other, “You don’t know what you are talking about!”. The second one says, “What do you mean by know? What do you mean by talking? What do you mean by you?” and so on.

Richard Feynman (1918-1988) American physicist
The Feynman Lectures on Physics, Volume I, 8-2 “Motion” (20 Oct 1961)
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But there is one feature I notice that is generally missing in Cargo Cult Science. That is the idea that we all hope you have learned in studying science in school — we never explicitly say what this is, but just hope that you catch on by all the examples of scientific investigation. It is interesting, therefore, to bring it out now and speak of it explicitly. It’s a kind of scientific integrity, a principle of scientific thought that corresponds to a kind of utter honesty — a kind of leaning over backwards. For example, if you’re doing an experiment, you should report everything that you think might make it invalid — not only what you think is right about it: other causes that could possibly explain your results; and things you thought of that you’ve eliminated by some other experiment, and how they worked — to make sure the other fellow can tell they have been eliminated.

Richard Feynman (1918-1988) American physicist
“Cargo Cult Science,” commencement address, California Institute of Technology (1974)
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For a successful technology, reality must take precedence over public relations, for nature cannot be fooled.

Richard Feynman (1918-1988) American physicist
Rogers Commission Report into the Challenger Crash, Appendix F “Personal Observations on Reliability of Shuttle” (Jun 1986)

Full report
 
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Science is a wonderful thing if one does not have to earn one’s living at it.

Albert Einstein (1879-1955) German-American physicist
Letter to E. Holzapfel (Mar 1951) [Einstein Archive 59-1013]
 
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The most beautiful thing we can experience is the mysterious. It is the source of all true art and science. He to whom this emotion is a stranger, who can no longer pause to wonder and stand rapt in awe, is as good as dead: his eyes are closed. This insight into the mystery of life, coupled though it may be with fear, has also given rise to religion. To know that what is impenetrable to us really exists, manifesting itself as the highest wisdom and the most radiant beauty which our dull faculties can comprehend only in their most primitive forms — this knowledge, this feeling, is at the center of true religiousness. In this sense, and in this sense only, I belong in the ranks of devoutly religious men.

Einstein - sense of the mysterious - wist_info quote

Albert Einstein (1879-1955) German-American physicist
“What I Believe,” Forum and Century (Oct 1930)
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Einstein crafted and recrafted his credo multiple times in this period, and specifics are often muddled by differing translations and by his reuse of certain phrases in later writing. The Forum and Century entry appears to be the earliest. Some important variants:

The most beautiful experience we can have is the mysterious. It is the fundamental emotion that stands at the cradle of true art and true science. Whoever does not know it and can no longer wonder, no longer marvel, is as good as dead, and his eyes are dimmed. It was the experience of mystery -- even if mixed with fear -- that engendered religion. A knowledge of the existence of something we cannot penetrate, our perceptions of the profoundest reason and the most radiant beauty, which only in their most primitive forms are accessible to our minds: it is this knowledge and this emotion that constitute true religiosity. In this sense, and only this sense, I am a deeply religious man.

— "The World As I See It [Mein Weltbild]" [tr. Bargmann (1954)]


The fairest thing we can experience is the mysterious. It is the fundamental emotion which stands at the cradle of true art and true science. He who knows it not and can no longer wonder, no longer feel amazement, is as good as dead, a snuffed-out candle. It was the experience of mystery -- even if mixed with fear -- that engendered religion. A knowledge of the existence of something we cannot penetrate, of the manifestations of the profoundest reason and the most radiant beauty, which are only accessible to our reason in their most elementary forms -- it is this knowledge and this emotion that constitute the truly religious attitude; in this sense, and in this alone, I am a deeply religious man.

— "The World As I See It [Mein Weltbild]" [tr. Harris (1934)]


The most beautiful and deepest experience a man can have is the sense of the mysterious. It is the underlying principle of religion as well as all serious endeavor in art and science. He who never had this experience seems to me, if not dead, then at least blind. To sense that behind anything that can be experienced there is a something that our mind cannot grasp and whose beauty and sublimity reaches us only indirectly and as a feeble reflection, this is religiousness. In this sense I am religious.

[Das Schönste und Tiefste, was der Mensch erleben kann, ist das Gefühl des Geheimnisvollen. Es liegt der Religion sowie allem tieferen Streben in Kunst und Wissenschaft zugrunde. Wer dies nicht erlebt hat, erscheint mir, wenn nicht wie ein Toter, so doch wie ein Blinder. Zu empfinden, dass hinter dem Erlebbaren ein für unseren Geist Unerreichbares verborgen sei, dessen Schönheit und Erhabenheit uns nur mittelbar und in schwachem Widerschein erreicht, das ist Religiosität. In diesem Sinne bin ich religiös.]

Variant in "My Credo [Mein Glaubensbekenntnis]" (Aug 1932)


See parallel sentiments here, here, and here.
 
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I am enough of an artist to draw freely upon my imagination. Imagination is more important than knowledge. For knowledge is limited, whereas imagination embraces the entire world, stimulating progress, giving birth to evolution.

Einstein - imagination is more important than knowlege - wist_info quote

Albert Einstein (1879-1955) German-American physicist
“What Life Means to Einstein,” Interview with G. Viereck, Saturday Evening Post (26 Oct 1929)
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Quoted as "I am enough of an artist to draw freely upon my imagination. Imagination is more important than knowledge. Knowledge is limited. Imagination encircles the world," in Viereck, Glimpses of the Great (1930).
 
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The inexperienced, and crackpots, and people like that, make guesses that are simple, but you can immediately see that they are wrong, so that does not count. Others, the inexperienced students, make guesses that are very complicated, and it sort of looks as if it is all right, but I know it is not true because the truth always turns out to be simpler than you thought.

Richard Feynman (1918-1988) American physicist
The Character of Physical Law, ch 7 “Seeking New Laws” (1965)
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We must trust the perfection of the creation so far, as to believe that whatever curiosity the order of things has awakened in our minds, the order of things can satisfy.

Ralph Waldo Emerson
Ralph Waldo Emerson (1803-1882) American essayist, lecturer, poet
“Nature,” Introduction, Nature: Addresses and Lectures (1849)
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Scientists take it for granted that it is perfectly consistent to be unsure — that it is possible to live and not know. But I don’t know whether everyone realizes that this is true.

Richard Feynman (1918-1988) American physicist
What Do You Care What Other People Think? (1988)
 
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When, however, the lay public rallies round an idea that is denounced by distinguished but elderly scientists and supports that idea with great fervor and emotion — the distinguished but elderly scientists are then, after all, probably right.

Isaac Asimov (1920-1992) Russian-American author, polymath, biochemist
Fantasy & Science Fiction (in answer to Clarke’s First Law) (1977)

See Clarke.
 
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The first principle is that you must not fool yourself — and you are the easiest person to fool.

Richard Feynman (1918-1988) American physicist
“Cargo Cult Science,” commencement address, California Institute of Technology (1974)
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I have no doubt that in reality the future will be vastly more surprising than anything I can imagine. Now my own suspicion is that the Universe is not only queerer than we suppose, but queerer than we can suppose.

J.B.S. Haldane (1892-1964) English geneticist [John Burden Sanderson Haldane]
“On Being the Right Size,” Possible Worlds and Other Papers (1927)

Sometimes attributed to Arthur Stanley Eddington.
 
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I do not know what I may appear to the world; but to myself I seem to have been only like a boy playing on the sea-shore, and diverting myself in now and then finding a smoother pebble or a prettier shell than ordinary, whilst the great ocean of truth lay all undiscovered before me.

Isaac Newton (1642-1727) English physicist and mathematician
Memoirs of the Life, Writings, and Discoveries of Sir Isaac Newton, 2.27 [ed. D. Brewster (1855)]
 
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Life is the art of drawing sufficient conclusions from insufficient premises.

Samuel Butler (1835-1902) English novelist, satirist, scholar
The Note-Books of Samuel Butler, ch. 1 “Life,” ix (1912)

Full text.
 
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Results! Why, man, I have gotten a lot of results! I know several thousand things that won’t work.

Thomas Edison (1847-1931) American inventor and businessman
(Attributed)
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When told by an associate, Walter S. Mallory, that it was a shame that several months of work on new battery technology hadn't yielded any results. Recorded in Dyer and Martin, Edison: His Life and Inventions, Vol. 2, ch. 24 (1910) as an anecdote by Mallory.

More discussion about this quotation's origins and variants: I Have Gotten a Lot of Results! I Know Several Thousand Things That Won’t Work – Quote Investigator.
 
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The most exciting phrase to hear in science, the one that heralds new discoveries, is not “Eureka!” but “That’s funny…”

Isaac Asimov (1920-1992) Russian-American author, polymath, biochemist
(Attributed)

Unsourced. More information here.
 
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For there is no comparison between that which we may lose by not trying and by not succeeding; since by not trying we throw away the chance of an immense good; by not succeeding we only incur the loss of a little human labour. But as it is, it appears to me from what has been said, and also from what has been left unsaid, that there is hope enough and to spare, not only to make a bold man try, but also to make a sober-minded and wise man believe.

[Non enim res pari periculo non tentatur, et no succedit; cum in illo ingentis boni, in hoc exiguae humanae operae, jactura vertatur. Verum ex dictis, atque etiam ex non dictis, visum est nobis spei abunde subesse, non tantum homini strenuo ad experiendum, sed etiam prudenti et sobrio ad credendum.]

Francis Bacon (1561-1626) English philosopher, scientist, author, statesman
Instauratio Magna, Part 2 “Novum Organum” [The New Organon],” Book 1, Aphorism # 114 (1620) [tr. Spedding (1858)]
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(Source (Latin)). Alternate translations:

For the risk attending want of success is not to be compared with that of neglecting the attempt; the former is attended with the loss of a little human labour, the latter with that of an immense benefit. For these and other reasons, it appears to us that there is abundant ground to hope, and to induce not only those who are sanguine to make experiment, but even those who are cautious and sober to give their assent.
[tr. Wood (1831)]

For it is not a case where there is an equal risk in not trying and not succeeding; since in the former instance we risk a huge advantage; in the latter a little human labour is thrown away. But from what has been said, and also from what has not been said, it seems to us that there is abundant ground of hope, not only to justify a stout-hearted man in trying, but even a prodent and sober man in believing.
[tr. Johnson (1859)]

For the danger of not trying and the danger of not succeeding are not equal, since the former risks the loss of great good, the latter of a little human effort. But from what we have said and from other things which we have not said, it has seemed to us that we have abundance of hope, whether we are men who press forward to meet new experiences, or whether we are careful and slow to believe.
[tr. Silverthorne (2000) "The Great Renewal"]

The loss that may come from not trying is much greater than what may come from trying and not succeeding: by not trying we throw away the chance of an immense good; by not succeeding we only incur the loss of a little human labour. But from what I have said (and from some things that I haven’t said) it seems to me that there is more than enough hope not only to get a vigorous man to try but also to make a sober-minded and wise man believe that he will succeed.
[tr. Bennett (2017)]

 
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Any sufficiently advanced technology is indistinguishable from magic.

Arthur C. Clarke (1917-2008) British writer
Profiles of the Future, “Hazards of Prophecy: The Failure of Imagination” (Clarke’s Third Law) (1962; rev. 1973)
 
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I have argued flying saucers with lots of people. … I was interested in this: they keep arguing that it is possible. And that’s true. It is possible. They do not appreciate that the problem is not to demonstrate whether it’s possible or not, but whether it’s going on or not. Whether it’s probably occurring or not, not whether it could occur.

Richard Feynman (1918-1988) American physicist
The Meaning of It All (1998)
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The least questioned assumptions are often the most questionable.

Paul Broca (1824-1880) French pathologist, neurosurgeon, anthropologist
“Quelques propositions sur les tumeurs dites cancéreuses” (16 Apr 1849)
 
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Facts are stubborn things; and whatever may be our wishes, our inclinations, or the dictates of our passions, they cannot alter the state of the facts and evidence.

John Adams (1735-1826) American lawyer, Founding Father, statesman, US President (1797-1801)
“Argument in Defense of the Soldiers in the Boston Massacre Trials” (4 Dec 1770)
 
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History warns us, however, that it is the customary fate of new truths to begin as heresies and to end as superstitions; and, as matters now stand, it is hardly rash to anticipate that, in another twenty years, the new generation, educated under the influences of the present day, will be in danger of accepting the main doctrines of the ‘Origin of Species’ with as little reflection, and it may be with as little justification, as so many of our contemporaries, twenty years ago, rejected them. Against any such a consummation let us all devoutly pray; for the scientific spirit is of more value than its products, and irrationally held truths may be more harmful than reasoned errors.

T. H. Huxley (1825-1895) English biologist [Thomas Henry Huxley]
“The Coming of Age of The Origin of Species,” lecture, Royal Institution (19 Mar 1880)
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First printed in Nature: A Weekly Illustrated Journal of Science (6 May 1880).
 
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